ABSTRACT
Introduction: Although several factors contributed to the rates of infection and mortality of the SARS-CoV-2 pandemic, obesity seemed to have played a larger role than most within the first several months of the pandemic. In addition, both preexisting health conditions and poor environmental condi-tions seemed to have added to higher levels of infection and mortality in several regions of the country. This study aimed to explore the impact of public health, socio-economic and environmental factors on the rate of infection and mortality of SARS-CoV-2 on gender and age groups in Peru.Methods: We explored the relationships, using Pearson's correlation and stepwise linear regression, between the in-fection and mortality cases per 100,000 individuals with pub-lic health data (obesity prevalence, total number of health in-frastructure, hypertension prevalence, active smokers, tuberculosis cases freely available from the Ministry of Health of Peru), socio-economic data (health needs not met, child-hood malnutrition, access to potable water, access to chlori-nated water system from National Institute of Statistics and Informatics of Peru) and environmental data (NO2 concen-tration from the Sentinel-2 satellite) in Peru. We used con-firmed cases from the 26 department level jurisdictions from 2020, before known variants were registered within the country and focused on gender and age groups, as well as case-fatality rate.Results: Multiple linear regression models indicate obe-sity, air quality, access to chlorinated water system, and prevalence of smoking are influential factors in the distribu-tion of infection and mortality for middle-age and elderly fe-male and male groups, but prevalence of TB and health needs not met were more important for children and young adults in Peru. Case-fatality rate was weakly associated with NO2 concentration.Conclusions: Obesity, exposure to poor air quality, and so-cio-economic conditions are significant factors in the morality of individuals above the age of 40 for both men and women, while other health factors appear to be more important to those younger than 40. The combination of these factors played a significant role during the first wave of SARS-CoV-2 infection in Peru in 2020.